William Seward, an abolitionist who wanted to be President in 1860 but supported Lincoln when he became the Republican Party’s nominee, was home the evening of April 14, 1865. Actually, he was in bed recuperating from injuries he had sustained in a carriage accident.
Lewis Payne intended to assassinate Seward at home while Booth killed Lincoln at Ford’s Theater. The indictment against Payne, read at the trial of the accused assassination conspirators, details what happened:
...Lewis Payne did, on the same night of the 14th day of April, A.D. 1865, about the same hour of 10 o’clock and 15 minutes P.M., at the City of Washington, and within the military department and the military lines aforesaid, unlawfully and maliciously make an assault upon...William H. Seward...in the dwelling-house and bed-chamber of him...and the said Payne did, then and there, with a large knife held in his hand, unlawfully, traitorously, and in pursuance of said conspiracy, strike, stab, cut, and attempt to kill and murder the said William H. Seward, and did thereby, then and there, with intent aforesaid, with said knife, inflict upon the face and throat of the said William H. Seward divers grievous wounds.
Had it not been for the neck brace Seward was wearing, as a result of his accident, Payne would have killed him. Instead, the Secretary of State lived to have his name associated with "Seward’s Folly" - the purchase of Alaska, from Russia, which he negotiated for $7.2 million. (The links take you to the actual Russian document and the “paid” U.S. Treasury Warrant of $7.2 million.) The Alaskan town of Seward (founded in 1903) is named for him.
...Lewis Payne, in further prosecution of said conspiracy...did attempt, with the knife aforesaid, and a pistol held in his hand, to kill and murder Frederick W. Seward, Augustus H. Seward, Emrick W. Hansell, and George F. Robinson, who were then striving to protect and rescue the said William H. Seward from murder by the said Lewis Payne, and did, then and there, with said knife and pistol held in his hands, inflict upon the head of...Frederick W. Seward, and upon the persons of...Augustus H. Seward, Emrick W. Hansell, and George F. Robinson, divers grievous and dangerous wounds...
Only Lewis Payne died as a result of what he did that night.